Hello,
I use a web frontend for work that runs locally on my server over X2Go for about one year with success.
Some months ago I noticed a significant decrease in performance when using Firefox. My server is running Ubuntu 16.04 with MATE desktop, Windows 10 client. Up to Firefox version 39.0.3 performance of loading pages, scrolling, browsing etc. was nearly flawless over a 5Mbit WAN link (with the exception of embedded video elements). However it seems the release of Firefox version 40.0 introduced some changes in rendering (see
https://www.mozilla.org/en-US/firefox/40.0/releasenotes/) that do not play nice with X2Go. Further reduction in performance was noticed in versions 46.0 and 48.0. The current release (48.0) even has trouble rendering a plain text document without lag and choppiness.
I have tried toggling various flags relating to graphics, compositing, rendering, etc. to no avail.